منابع مشابه
Aggressive B-Cell Lymphomas
Aggressive B-cell lymphomas (ABLs) are a group of B-cell malignancies, that is, a relatively common form of cancer across the world. This issue on aggressive B-cell lymphomas compiles 12 exciting manuscripts, most of which are very meticulously performed reviews of the available current literature. Three areas of lymphoma pathology and biology that are leading to a greater understanding of rela...
متن کاملTargeting aggressive B-cell lymphomas with cell-penetrating peptides.
DLBCL (diffuse large B-cell lymphoma) is the most common subtype of non-Hodgkin's lymphoma. Current therapy for patients includes chemotherapy and monoclonal antibodies. Although oncogene-targeted therapy is dramatically successful for patients with certain kinds of leukaemias, there are no such agents yet for DLBCL. One reason for this is that several key oncogenes involved in DLBCL pathogenes...
متن کاملMicroenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas
Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The ca...
متن کاملEpigenetics, c-Myc and Aggressive B-cell Lymphomas
c-Myc (hereafter referred to as Myc) protein plays a fundamental role in cell cycle regulation, proliferation, differentiation, and apoptosis by modulating the expression of a large number of targets [1]. Expression of Myc is frequently deregulated in human cancers and is often associated with aggressive disease. In non-Hodgkin lymphomas, although Myc has been described as a defining feature an...
متن کاملUnderstanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification.
MYC is a potent oncogene initially identified as the target of the t(8;14)(q24;q32) chromosome translocation in Burkitt lymphoma. MYC gene alterations have been identified in other mature B-cell neoplasms that are usually associated with an aggressive clinical behavior. Most of these tumors originate in cells that do not normally express MYC protein. The oncogenic events leading to MYC up-regul...
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ژورنال
عنوان ژورنال: Advances in Hematology
سال: 2012
ISSN: 1687-9104,1687-9112
DOI: 10.1155/2012/604603