Aggregation and fusion of modified low density lipoprotein
نویسندگان
چکیده
منابع مشابه
Phospholipase D-modified Low Density Lipoprotein
Macrophage uptake of modified forms ofLDL leads to cellular cholesterol accumulation. Upon incubation of LDL with phospholipase D (PLase D), a timeand enzyme dose-dependent production of phosphatidic acid (PA), paralleled by a rapid reduction in LDL phosphatidyl choline content (up to 65% within 15 min of incubation) was noted. No lipid peroxidation could be found in PLase D-modified LDL. Upon ...
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A is an inflammatory disease characterized by the appearance of small extracellular lipid droplets, formation of foam cells, and secretion of pro-inflammatory cytokines by vascular cells in the arterial intima. There is substantial evidence that the extracellular lipid droplets are derived directly from aggregated and fused low density lipoprotein (LDL) particles. However, native LDL particles ...
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We have shown previously that low density lipoprotein (LDL) subjected to vortexing forms self-aggregates that are avidly phagocytosed by macrophages. That phagocytic uptake is mediated by the LDL receptor. We now show that LDL self-aggregation is strongly inhibited (80-95%) by the presence of high density lipoprotein (HDL) or apolipoprotein (apo) A-I. Another type of LDL aggregation, namely tha...
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Incubation of mouse peritoneal macrophages with native human low density lipoprotein (LDL) did not cause any significant storage of intracellular cholesteryl esters. However, when the LDL was subjected to brief (30-second) vortexing, it formed self-aggregates that were rapidly ingested and degraded by macrophages, converting them to cholesteryl ester-rich foam cells. Such aggregates were as pot...
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In this study we assessed whether low density lipoproteins (LDL) isolated from minced aortic atherosclerotic plaques obtained at autopsy (A-LDL) shared structural and functional properties with LDL oxidized by incubation with Cu2+ for 8-18 hours at 20 degrees C (Ox-LDL). Although both A-LDL and Ox-LDL represented monomeric particles about the size of LDL, both differed from LDL in that they sho...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1996
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)37467-8