Aggravation of gastric lesions by leukotriene C4 in rats
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چکیده
منابع مشابه
Protective Effect of Crocin on Gastric Mucosal Lesions Induced by Ischemia-Reperfusion Injury in Rats
The present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats.Forty male rats were randomly divided into sham, control (I/R injury) and three crocin-pretreated groups. To induce I/R lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. Pretreated-rats rec...
متن کاملProtective Effect of Crocin on Gastric Mucosal Lesions Induced by Ischemia-Reperfusion Injury in Rats
The present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats.Forty male rats were randomly divided into sham, control (I/R injury) and three crocin-pretreated groups. To induce I/R lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. Pretreated-rats rec...
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Materials and Methods. Wistar rats weighing 434 to 478 g were anesthetizedith ketamine (87 mg/kg) and xylazine (13 mg/kg) injected intramuscularly. PE-10 polyethylene catheters were inserted into the femoral artery and vein. The arterial catheter was connected to a blood pressure transducer and systemic arterial blood pressure was continuously imonitored. Buffered evans blue (0.75 ml) was injec...
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Background/Aim: Recent studies suggested a risk of gastric adverse reaction on the concomitant use of antiplatelet drugs with NSAIDs. The present study was performed to examine the adverse effects of anti-platelet drug clopidogrel, a P2Y12 receptor antagonist, on gastric antral lesions induced by conventional NSAIDs in refed
متن کاملTaurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver.
BACKGROUND/AIMS Cysteinyl-containing leukotrienes seem to exert a cholestatic effect. However, leukotriene inhibitors were found to reduce bile salt efflux in isolated rat hepatocytes, suggesting a role for leukotrienes in bile flow formation. METHODS In the isolated rat liver, the effects of two different concentrations of leukotriene C4 on bile flow and bile salt excretion are analyzed, as ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1989
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)56419-8