Aggravation of Allergic Airway Inflammation by Cigarette Smoke in Mice Is CD44-Dependent

Aggravation of Allergic Airway Inflammation by Cigarette Smoke in Mice Is CD44-Dependent

BACKGROUND Although epidemiological studies reveal that cigarette smoke (CS) facilitates the development and exacerbation of allergic asthma, these studies offer limited information on the mechanisms involved. The transmembrane glycoprotein CD44 is involved in cell adhesion and acts as a receptor for hyaluronic acid and osteopontin. We aimed to investigate the role of CD44 in a murine model of ...

Chrysin suppresses cigarette smoke-induced airway inflammation in mice.

Cigarette smoke-induced airway inflammation is one of the most important features of chronic airway diseases. Studies suggest that chrysin possesses strong anti-inflammatory properties and this study aimed to investigate the effect of chrysin on cigarette smoke-induced airway inflammation in mice. Mice with exposure to cigarette smoke were intraperitonealy injected with chrysin (10, 20 mg/kg·d)...

Inflammation in Mice A20 Attenuates Allergic Airway

Cigarette smoke exposure facilitates allergic sensitization in mice

BACKGROUND Active and passive smoking are considered as risk factors for asthma development. The mechanisms involved are currently unexplained. OBJECTIVE The aim of this study was to determine if cigarette smoke exposure could facilitate primary allergic sensitization. METHODS BALB/c mice were exposed to aerosolized ovalbumin (OVA) combined with air or tobacco smoke (4 exposures/day) daily ...

Effects of hardwood smoke exposure on allergic airway inflammation in mice.

Hardwood smoke (HWS) from wood burning stoves and fireplaces can be a significant contributor to the composition of ambient air pollution. We hypothesize that the inhalation of HWS by ovalbumin (OVA)-sensitized mice with preexisting lung inflammation leads to the exacerbation of allergic airway responses. Two different models were employed to characterize the effects of inhaled wood smoke on al...