منابع مشابه
Aged muscle lacks sparks
609 M uscle activity is driven by spikes of calcium release. Weisleder et al. (page 639) fi nd that aged muscles, when compared with young muscles, have reduced Ca 2+ release following stimulation. The dampened response may be caused by a failure to maintain robust membranous compartments that can respond to an input with a single output. Previous work from the group showed that Ca 2+ sparks ca...
متن کاملSparks in Frog Skeletal Muscle
Calcium sparks are brief, highly localized elevations of [Ca 2 ], which arise spontaneously or can be evoked by depolarization in many types of muscle cells. The Ca 2 is released into the cytoplasm from intracellular stores (the SR) through the SR Ca 2 release channels (the RYR). Since their discovery (in cardiac muscle; Cheng et al., 1993), Ca 2 sparks have attracted substantial attention. The...
متن کاملSparks of Frog Skeletal Muscle
An algorithm for the calculation of Ca 2 1 release flux underlying Ca 2 1 sparks (Blatter, L.A., J. Hüser, and E. Ríos. 1997. Proc. Natl. Acad. Sci. USA. 94:4176–4181) was modified and applied to sparks obtained by confocal microscopy in single frog skeletal muscle fibers, which were voltage clamped in a two-Vaseline gap chamber or permeabilized and immersed in fluo-3–containing internal soluti...
متن کاملCalcium sparks in smooth muscle.
Local intracellular Ca(2+) transients, termed Ca(2+) sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca(2+) release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca(2+) sparks are activated by Ca(2+) entry through dihydropyridine-sensitive voltage-dependent Ca(2+) channels, although the precise mechanisms of communication of Ca(2+) entry to Ca(...
متن کاملCalcium Sparks Unleashed in Vascular Smooth Muscle
Hypertension is a progressive disease involving an increase in arterial constriction. It constitutes a major risk factor leading to stroke, heart disease, and kidney failure. Understanding the molecular pathways involved in arterial tone regulation is crucial to increasing our understanding of blood pressure regulation. Recently, a novel mechanism involving small-localized bursts of calcium ins...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1745iti2