Age-related gene expression profiles of immature human oocytes
نویسندگان
چکیده
منابع مشابه
Vitrification Affects Nuclear Maturation and Gene Expression of Immature Human Oocytes
Background: Vitrification of oocytes is a fast-freezing technique, which may affect the quality of the human oocyte, and consequently affects the embryo development, pregnancy and birth. The aim of the current study was to investigate the consequence of in-vitro vitrification on maturation status of immature human oocytes, additionally, expression levels of stress, and apoptosis related genes. ...
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BACKGROUND The development competence of human oocytes declines with increasing age. The objective of this study was to investigate the effect of age on gene expression profile in mature human oocytes. METHODS mRNA was isolated for whole genome gene expression microarray analysis from metaphase II (MII) oocytes donated by IVF or ICSI patients [10 women aged <36 years (younger) and five women ...
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The cryopreservation of immature GV oocytes by vitrification is offering attractive perspectives, since they represent an important pool of germ cells for women undergoing IVM cycles, or at risk of infertility for OHSS or PCOs, particularly those poor responders to gonadotropin stimulation, or in case of cancer. Therefore, it becomes necessary to optimize both cryopreservation technique as well...
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In vitro fertilization, one of assisted reproduction`s technique is, for some couples, the only possibility to conceive a child. One of the main condition that must be fulfield in order to reach this goal is the quality of human oocytes. The ovarian stimulation protocols used have as an important goal the oocytes quality. The maturity grade of the oocytes is a good indicator of their quality.Th...
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Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcript...
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ژورنال
عنوان ژورنال: MHR: Basic science of reproductive medicine
سال: 2018
ISSN: 1460-2407
DOI: 10.1093/molehr/gay036