Age-related changes in thrombopoietin in children: reference interval for serum thrombopoietin levels
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چکیده
منابع مشابه
Serum thrombopoietin levels in cyclic thrombocytopenia.
Cyclic thrombocytopenia is a rare disorder characterized by periodic decreases and increases in platelet levels. Recent data suggest these fluctuations result from periodic failure of effective platelet production or periodic immune-mediated platelet destruction.’.’ However, the pathogenesis of this disorder is uncertain. We developed an enzyme-linked immunosorbent assay (ELISA) of serum thromb...
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Little is known about the behaviour of endogenous thrombopoietin (TPO) serum levels during rapid sequences of dose-intensified chemotherapy. To characterize the relationship between TPO levels and platelet counts in this setting we serially measured both parameters over the entire treatment period of patients receiving multicycle polychemotherapy. We found TPO and platelet responses to be gener...
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Forty patients with liver cirrhosis (LC), (27 males/13 females, mean age 53.3±1.7 years, range 17-65) were included. Cirrhosis etiology was hepatitis B (HBV) and C (HCV) viruses (22 patients), alcohol (8 patients) and miscellaneous causes (10 patients). The patients were classified according to the Child score into three groups of clinical severity: A, B, and C. (Child A: n=26, Child B and C: n...
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The pathophysiology of thrombocytopenia in the syndrome of thrombocytopenia with absent radii (TAR) is not yet understood. We examined thrombopoietin (TPO) serum levels and the in vitro reactivity of platelets to TPO in five patients affected with TAR syndrome. We found elevated TPO serum levels in all patients tested, excluding a TPO production defect as cause for thrombocytopenia in TAR syndr...
متن کاملThrombopoietin.
By Shirley Ebbe I T HAS BEEN CLEAR for almost 20 years that platelet production is subject to homeostatic regulatory mechanisms that result in stimulation when the platelet count is li w’ and suppression when it is high.2 In spite of elapsed time, the physiologic processes that are involved in those regulatory mechanisms are not clear. Thrombocytopoiesis may be regulated by a humoral thrombopoi...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1999
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.1999.01641.x