Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)
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چکیده
منابع مشابه
Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)
INTRODUCTION Critical care patients frequently receive blood transfusions. Some reports show an association between aged or stored blood and increased morbidity and mortality, including the development of transfusion-related acute lung injury (TRALI). However, the existence of conflicting data endorses the need for research to either reject this association, or to confirm it and elucidate the u...
متن کاملTransfusion-related acute lung injury (TRALI).
Transfusion is an inevitable event in the life of many individuals. Transfusion medicine personnel attempt to provide blood products that will result in a safe and harmless transfusion. However, this is not always possible since no laboratory test gives totally accurate and reliable results all the time and testing in routine transfusion services is devoted primarily to the identification of re...
متن کاملTransfusion-Related Acute Lung Injury (TRALI) and Strategies for Prevention
Background: Transfusion-Related Acute Lung Injury (TRALI) is a serious complication of blood transfusion. In recent years, TRALI has been reliably shown to be the most common cause of transfusion-related fatalities in the United States and in the United Kingdom. Its prevalence is about 1 in 1323 transfused components; however, it is often under diagnosed. Classically, TRALI present as noncardio...
متن کاملTRANSFUSION MEDICINE Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury
Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion and has been ranked as one of the leading causes of transfusion-related fatalities. Nonetheless, many details of the immunopathogenesis of TRALI, particularly with respect to recipient factors are unknown. We used a murine model of antibody-mediated TRALI in an attempt to understand the role that recipient ly...
متن کاملTransfusion-related acute lung injury (TRALI): current concepts and misconceptions.
Transfusion-related acute lung injury (TRALI) is the most common cause of serious morbidity and mortality due to hemotherapy. Although the pathogenesis has been related to the infusion of donor antibodies into the recipient, antibody negative TRALI has been reported. Changes in transfusion practices, especially the use of male-only plasma, have decreased the number of antibody-mediated cases an...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2012
ISSN: 1364-8535
DOI: 10.1186/cc11178