AGE-DEPENDENT DOSE-RESPONSE RELATIONSHIP OF ORG NC45 IN ANAESTHETIZED PATIENTS
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منابع مشابه
Pharmacokinetics of Org NC45 (norcuron) in patients with and without renal failure.
To determine the influence of renal failure on the pharmacokinetics and neuromuscular blockade of Org NC 45 (Norcuron), a new monoquaternary homologue of pancuronium, 13 patients under halothane and nitrous oxide anesthesia were studied. Org NC 45 was administered by 2-min infusion in doses of 0.28 mg kg-1 (normal renal function group, n = 4) and 0.14 mg kg-1 (renal failure group, n = 5). Four ...
متن کاملInfluence of suxamethonium on the potency of ORG NC 45 in anaesthetized patients.
The non-depolarizing neuromuscular block produced by Org NC 45 was potentiated by the previous administration of suxamethonium 1 mg kg-1, shown by twitch depression of 91.3 +/- 2.4% when the same dose of Org NC 45 was administered after recovery from suxamethonium compared with the control value of 71.9 +/- 6.5%. The recovery index was also prolonged from 8.1 +/- 0.3 to 10.4 +/- 1.0 min after s...
متن کاملDose-response relation for atracurium, ORG NC 45 and pancuronium.
The potencies of atracurium, Org NC 45 and pancuronium were determined using cumulative dose-response curves. The effective doses producing 95% twitch depression were 279 microgram kg-1, 56 microgram kg-1 and 64 microgram kg-1 respectively, the relative potency being 1:5.0:4.3. The calculated log-probit dose-response curves showed the steepest slope for pancuronium, although the slopes did not ...
متن کاملNaloxone: dose-dependent antagonism of respiratory depression by fentanyl in anaesthetized patients.
Naloxone was used to antagonize the respiratory depression caused by the administration of fentanyl 0.05 mg to patients anaesthetized with 0.5% halothane in 70% nitrous oxide in oxygen. Four groups of at least 10 patients each were studied. Doses of 0.1, 0.2 and 0.4 mg of naloxone were given, and an effect proportional to the logarithm of the dose was demonstrated.
متن کاملRelative potency of ORG NC 45, pancuronium, alcuronium and tubocurarine in anaesthetized man.
The relative potency, time-course of action and cardiovascular effects of Org NC 45, a new non-depolarizing neuromuscular blocking agent, have been compared with those of pancuronium, alcuronium and tubocurarine in 64 anaesthetized patients. The relative potency (ED50) to Org NC 45 was 1.74, 3.69 and 8.57 respectively. In doses which caused useful surgical relaxation, duration of action of Org ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1982
ISSN: 0007-0912
DOI: 10.1093/bja/54.6.653