Affinity-based target deconvolution of safranal

affinity based target deconvolution of safranal

Exploiting polypharmacology for drug target deconvolution.

Polypharmacology (action of drugs against multiple targets) represents a tempting avenue for new drug development; unfortunately, methods capable of exploiting the known polypharmacology of drugs for target deconvolution are lacking. Here, we present an ensemble approach using elastic net regularization combined with mRNA expression profiling and previously characterized data on a large set of ...

Target deconvolution techniques in modern phenotypic profiling.

The past decade has seen rapid growth in the use of diverse compound libraries in classical phenotypic screens to identify modulators of a given process. The subsequent process of identifying the molecular targets of active hits, also called 'target deconvolution', is an essential step for understanding compound mechanism of action and for using the identified hits as tools for further dissecti...

Wavespace-Based Coherent Deconvolution

Array deconvolution is commonly used in aeroacoustic analysis to remove the influence of a microphone array’s point spread function from a conventional beamforming map. Unfortunately, the majority of deconvolution algorithms assume that the acoustic sources in a measurement are incoherent, which can be problematic for some aeroacoustic phenomena with coherent, spatially-distributed characterist...

Framelet Based Deconvolution

In this paper, two framelet based deconvolution algorithms are proposed. The basic idea of framelet based approach is to convert the deconvolution problem to the problem of inpainting in a frame domain by constructing a framelet system with one of the masks being the given (discrete) convolution kernel via the unitary extension principle of [26], as introduced in [6, 7, 8, 9] . The first algori...