AF-2364 is a prospective spermicide candidate

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AF-2364 is a prospective spermicide candidate.

AbstractInhibition of sperm motility has recently become a promising target for male contraceptive development. AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague-Dawley rats. LND can also target mitochondria to inhibit oxygen consumption and block energy metabolism in tumour cells. However, there are no reports of the effects of AF-23...

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ژورنال

عنوان ژورنال: Asian Journal of Andrology

سال: 2010

ISSN: 1008-682X,1745-7262

DOI: 10.1038/aja.2010.11