Aerosol drug delivery to intubated neonates.
نویسندگان
چکیده
منابع مشابه
Aerosol Drug Delivery for Infants
INTRODUCTION Every year, approximately 2,500 children are admitted to the pediatric intensive care unit (PICU) at the Children’s Hospital of Pittsburgh at the University of Pittsburgh Medical Center alone [1]. Respiratory illnesses are one of the leading causes of admission [1]. For children with acute respiratory illnesses, inhaled medications are a common method of treatment, as this allows p...
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Delivery of drug aerosols to the lungs of ventilated neonates by metered dose inhaler and spacer (Aerochamber) and ultrasonic nebuliser (Pentasonic) was assessed using sodium cromoglycate. The mean proportion of a known intratracheal dose of sodium cromoglycate excreted in the urine of four intubated infants was 37.5%. After assuming that 38% of the sodium cromoglycate aerosol reaching the neon...
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BACKGROUND Assisted mechanical ventilation is the mainstay of management of a variety of conditions affecting the neonate. However there are a number of potential hazards associated with this life saving intervention. New suctioning techniques have been introduced into clinical practice which aim to prevent or reduce these untoward effects. OBJECTIVES To assess the effects of endotracheal suc...
متن کاملDevelopment of aerosol drug delivery with helium oxygen gas mixtures.
Aerosol drug delivery using helium-oxygen gas mixtures (heliox) is considered in terms of flow physics, atomization, and aerosol mechanics. Theoretical considerations are then related to past studies of the physiological effects of the inhalation of heliox and its potential use as a drug delivery medium. Past clinical trials of heliox investigating this use are reviewed and technical recommenda...
متن کاملEffects of Tumour-induced Flow Patterns on Aerosol Drug Delivery
This manuscript presents a theoretical study of fluid dynamics in diseased lungs. The objective was to describe fluid behavior and assist in the development of new techniques for targeted delivery of drugs. Numerical simulations were conducted using FIDAP on the Cray T90 supercomputer. Two lung bifurcations with tumors in tracheobronchial airways were considered. Weibel [1] lung morphology and ...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1992
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.67.7_spec_no.885