Advantame Sweetener Preference in C57BL/6J Mice and Sprague-Dawley Rats
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چکیده
منابع مشابه
Advantame sweetener preference in C57BL/6J mice and Sprague-Dawley rats.
Advantame is a new ultrahigh-intensity noncaloric sweetener derived from aspartame and approved for human use. Rats and mice are not attracted to the taste of aspartame and this study determined their preference for advantame. In 24-h choice tests with water, C57BL/6J mice and Sprague-Dawley rats were indifferent to advantame at concentrations of 0.01, 0.03, and 0.1mM but significantly preferre...
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A spontaneous tumor incidence of 45% was noted in 360 Sprague-Dawley rats (179 males and 181 females) and a 26% incidence was seen in 254 Swiss mice (101 males and 153 females) used as untreated control animals in an 18month series of carcinogenesis experiments. The percentage of female rats with tumors was almost double that of males, which difference was accounted for chiefly by the high inci...
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ژورنال
عنوان ژورنال: Chemical Senses
سال: 2015
ISSN: 0379-864X,1464-3553
DOI: 10.1093/chemse/bju070