Advances in Risk Prediction of Type 2 Diabetes: Integrating Genetic Scores With Framingham Risk Models: Table 1
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منابع مشابه
Advances in Risk Prediction of Type 2 Diabetes: Integrating Genetic Scores With Framingham Risk Models
Type 2 diabetes (T2D) is a worldwide epidemic affecting 8.3% of the current global adult population (1), with a growing prevalence in both developed and developing nations. It is estimated that of 29.1 million U.S. individuals with T2D, 8.1 million (27.8%) are undiagnosed—up from 7.0 million (27.1%) in 2010. T2D is strongly heritable, with estimates ranging from 30% to 70% (2). As elevated bloo...
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OBJECTIVE To evaluate current risk models and scores for type 2 diabetes and inform selection and implementation of these in practice. DESIGN Systematic review using standard (quantitative) and realist (mainly qualitative) methodology. Inclusion criteria Papers in any language describing the development or external validation, or both, of models and scores to predict the risk of an adult dev...
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The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD ...
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Type 2 diabetes (T2D) is a common disease caused by a complex interplay between many genetic and environmental factors. Candidate gene studies and recent collaborative genome-wide association efforts revealed at least 38 common single nucleotide polymorphisms (SNPs) associated with increased risk of T2D. Genetic testing of multiple SNPs is considered a potentially useful tool for early detectio...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2015
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db15-0033