Advances in Ergometry

Pitfalls of efficiency determination in cycling ergometry.

TO THE EDITOR: Muscular efficiency is a typical topic of traditional exercise physiology, but the results of seemingly simple approaches may be misinterpreted. There is a variety of pitfalls that have to be avoided during efficiency determination (e.g., Ref. 1). This is rather simple during cycling, because it is an uncomplicated movement mastered by nearly everybody; furthermore the amount of ...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

Reliability of cardiorespiratory measurements during wheelchair ergometry.

The purpose of this research was to evaluate the stability of measures of heart rate (HR) and oxygen uptake (VO2) during repeated 30-minute bouts of constant work-rate wheelchair ergometry. Ten able-bodied subjects (seven male; three female) completed three sequential, single-stage wheelchair ergometer propulsion tests, to exhaustion, at least 48 hours apart, to determine the reliability of mea...