Adult T-cell leukaemia/lymphoma-like human T-cell leukaemia virus-1 replication in infective dermatitis
نویسندگان
چکیده
منابع مشابه
The Enigma of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Infection in Iran
Human T-cell lymphotropic virus type-I (HTLV-I) was the first human retrovirus associated with malignancy. The prevalence of HTLV-I infection varies significantly in different regions of the world. In this study, the prevalence of HTLV-I infection among ethnic Jews living in Shiraz, South of Iran, was investigated. 286 blood samples were obtained. HTLV-1 antibody assay on serum samples was d...
متن کاملAdult T-cell leukaemia/lymphoma (ATLL) and T-cell leukemia virus type 1 (HTLV1)
Epidemiology The disease has a long latency, and affected individuals usually are exposed to the virus very early in life. The virus may be transmitted in breast milk, and through exposure to blood and blood products. The cumulative incidence of ATLL is estimated to be 2.5% among HTLV-1 carriers in Japan (1). Sporadic cases have been found in the United State and elsewhere. It occurs in adults ...
متن کاملHuman T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa
BACKGROUND The Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (IDH), is a chronic relapsing dermatitis which usually presents in children older than 2 years. A total of 300 cases have been reported worldwide (Latin America, the Caribbean and only 5 from Senegal). Neither IDH, nor its complications have been reported from the rest of Africa. We aimed to examine t...
متن کاملHuman T-cell lymphotropic virus type 1 infective dermatitis emerging in adulthood.
BACKGROUND Infective dermatitis (ID) is a rare dermatologic condition of childhood that has been linked to human T-cell lymphotropic virus type 1 (HTLV-1). OBJECTIVE To analyze the clinical and laboratory features associated with adult-onset ID linked to HTLV-1. METHODS From December 1995 to December 2007, four patients with ID were followed in the dermatology outpatient clinic of the "Hosp...
متن کاملActivation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells
HTLV-1 (human T-cell leukaemia virus type 1) is the causative agent for ATL (adult T-cell leukaemia). HTLV-1 Tax can activate the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway, which is responsible for survival of HTLV-1-infected T-cells. HIFs (hypoxia-inducible factors) are transcriptional regulators that play a central role in the response to hypoxia. Overexpression of HIF-1alpha in...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2003
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2003.04565.x