منابع مشابه
Adult Stem Cell Plasticity Defined
Introduction Investigators have postulated since the turn of the century that some cells in the body appear to participate in the formation of new cells to replace injured, aged, or infected cells in tissues and organs. The concept that certain specialized cells within an organ (stem cells) could give rise to mature functioning cells in that same organ has been demonstrated most clearly in the ...
متن کاملAdult stem cell plasticity: fact or artifact?
There has been unprecedented recent interest in stem cells, mainly because of the hope they offer for cell therapy. Adult stem cells are an attractive source of cells for therapy, especially in view of the recent claims that they are remarkably plastic in their developmental potential when exposed to new environments. Some of these claims have been either difficult to reproduce or shown to be m...
متن کاملSTEM CELL Stem cell plasticity
The quintessential stem cell is the embryonal stem (ES) cell which has unlimited self-renewal and multipotent differentiation potential. Stem cells have also been identified in most tissues. Compared with ES cells, tissue specific stem cells have less self-renewal ability and, although they differentiate into multiple lineages, they are not multipotent. A large number of recent published studie...
متن کاملPlasticity of Adult Stem Cells
Recent years have seen much excitement over the possibility that adult mammalian stem cells may be capable of differentiating across tissue lineage boundaries, and as such may represent novel, accessible, and very versatile effectors of therapeutic tissue regeneration. Yet studies proposing such "plasticity" of adult somatic stem cells remain controversial, and in general, existing evidence sug...
متن کاملRecipes for adult stem cell plasticity: fusion cuisine or readymade?
A large body of evidence supports the idea that certain adult stem cells, particularly those of bone marrow origin, can engraft at alternative locations, particularly when the recipient organ is damaged. Under strong and positive selection pressure these cells will clonally expand/differentiate, making an important contribution to tissue replacement. Similarly, bone marrow derived cells can be ...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2002
ISSN: 0022-3417,1096-9896
DOI: 10.1002/path.1176