Adult growth hormone deficiency guidelines: more difficult than it seems to incorporate into clinical practice universally

نویسندگان

چکیده

Adult growth hormone deficiency (GHD) is a syndrome characterized by adverse phenotypic, metabolic, and quality-of-life features. Over the past 2 decades, there accumulating evidence demonstrating improvement of most these parameters when GH optimally replaced. Appropriate selection patients at risk GHD crucial considering performing testing to establish diagnosis. While generally safe, replacement requires careful dose initiation monitoring assure effectiveness tolerance in treated patients. Several consensus clinical practice guidelines recommend evaluation adults presenting with hypothalamic-pituitary disorders for GHD. However, managing such varies among countries largely due lack recognition condition, availability, reimbursement drug, as demonstrated from large online survey prepared European Society Endocrinology involving 2148 Europe Australia. These data reinforce notion variability disease recognition, education adult amongst healthcare professionals, availability drug contributing under-utilization therapy several countries. This commentary article highlights fact that despite publication guideline recommendations positive long-term safety efficacy replacement, still need increased enhance awareness general population improve knowledge professionals administrators state allow early identification treatment optimization.

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ژورنال

عنوان ژورنال: European journal of endocrinology

سال: 2021

ISSN: ['1479-683X', '0804-4643']

DOI: https://doi.org/10.1530/eje-20-1455