Adult brainstem gliomas: Correlation of clinical and molecular features
نویسندگان
چکیده
منابع مشابه
Genetic and immune features of resectable malignant brainstem gliomas
We surveyed common genetic mutations (IDH1, H3F3A, PPM1D, and TP53) and immune features (PD-L1 expression and CD8+ T cell tumor infiltration) in a series of 62 malignant brainstem gliomas that were resected via microsurgery. IDH1 mutations were mutually exclusive with H3F3A mutations. IDH1 mutations appeared only in adults and occurred more frequently in tumors larger than 10cm3 (8/29 vs 1/32, ...
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Clinical studies have shown that gliomas of the brainstem behave differently in children and adults. The aim of the present study was to compare and analyze the differences between these gliomas in juvenile and adult rats with regard to tumor growth, survival, pathology and magnetic resonance imaging (MRI). A total of 25 juvenile and 25 adult Wistar rats were divided into groups A (15 juvenile ...
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Diffuse intrinsic pontine glioma (DIPG) is the most common type representing approximate‐ ly 80% of brainstem gliomas [5, 6]. They have a dismal prognosis with a median survival of only a year. Their natural history is often compared to but worse than that of supratentorial glioblastoma seen primarily in the adult population. Nondiffuse brainstem gliomas, includ‐ ing focal, dorsal exophytic and...
متن کاملAdult Brainstem Gliomas: Retrospective Analysis of 51 Patients.
AIM Brainstem gliomas (BSG) constitute less than 2% of brain tumors in adults. Therapeutic options are limited and BSG are associated with a high morbidity and mortality. MATERIAL AND METHODS We reviewed the records of 51 patients with BSG treated at the Institute of Neurosurgery, Clinical Center of Serbia in Belgrade between 1998 and 2012. We recorded demographic and clinical variables as we...
متن کاملFocal brainstem gliomas
ةيلمعلا ءانثأ ريوصتلا كلذكو ةروطتلما ةيبصعلا ةحلالما ةمظنأ حارج ةردق نم تززع ةيبصعلا ةيجولويزيفلا دصرلا ايجولونكتو يفو ،ةيرؤبلا غامدلا عذج ماروأ لاصئتسا نم باصعلأاو خلما هذه .ةحارجلل ةلباق ريغ ةرشتنلما غامدلا عذج ماروأ ربتعت لباقلما ،ينثحابلا سفنل اًقباس ترشن ةساردل ًارارمتسا ةيملعلا ةقرولا .غامدلا عذج ماروأ ريوصت اضيأو فينصتو صيخشت تشقان عذج ماروأ ةحارج بيلاسأو قرط نافلؤلما حرشي ةلاقلما هذه يف ء...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2015
ISSN: 0022-510X
DOI: 10.1016/j.jns.2015.04.014