Administration of Oral Gemitir Flower Extract (Tagetes erecta L) Increased The Number of Neovascularization, Fibroblasts Cell and Epithelization of Wound in Male Wistar Strains Rats (Rattus norvegicus)

Background: Herbal ingredients that can be used to reduce wound healing on the skin are administration of bioactive compounds from gemitir flowers (Tagetes erecta L) as an anti-inflammatory and antioxidant. This study prove oral extract increases number neovascularization, fibroblast cell epithelialization in male Wistar strains rats. Method: research is anexperimental with a randomized posttest-only control group design method. The subjects 28 rats (Rattus norvegicus), which were divided into 2 groups treatment groups. analytical method Shapiro-Wilk Test Levene’s then compared using one-way ANOVA post hoc least significant difference (LSD). Results: Neovascularization P0-4 P0-14 have same value 1.86±0.90,while P1-48.86±1.35and P1-14 decreased 5.00±1.15. Number cells: 8.29±3.25and P014:9.00±3.51cells/field view, while PI-4:18.57 ± 4.89 P1-14: 32.00 7.39. Epithelialization results described by epithelial thickness at P0-4: 28.08 10.07 µm P0-14:298.86±273.88µm, P1-4: 1096.71±133.93µm 1674.00± 331.55µm. one way p<0.001. LSD P0 (4) vs (14) not significantly different P1 (4), (14), all differed p<0.05. Conclusion: Oral ethanol increased neovascularization day 4 fibroblasts days 14.