ADMA and hyperhomocysteinemia

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Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes

NG-Methylation of L-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-L-arginine (MMA), NG,NG-dimethyl-L-arginine (asymmetric dimethylarginine, ADMA) and NG,N'G-dimethyl-L-arginine (symmetric dimethylarginine, SDMA). Biological MMA, ADMA and SDMA occur as free acids in the nM-range and as residues of proteins of la...

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Hyperhomocysteinemia, when considered as a causal factor of vascular diseases, has been subject of much discussion. Case-control, retrospective and prospective studies have identified a relationship between high plasma concentrations of homocysteine and vascular disease. The aim of the present review was to better understand the interrelation between plasma concentrations of homocysteine and va...

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Hyperhomocysteinemia and Atherosclerosis – an Overveiw

Indians are reported to have a very high prevalence of premature Coronary artery disease (CAD). A link between plasma homocysteine concentrations with vascular disease was first suggested by the observation made in patients with homocystinuria having arteriosclerosis. The recent interest in this topic has been generated by the evidence, that people with hyperhomocysteinemia have an increased ri...

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ژورنال

عنوان ژورنال: Vascular Medicine

سال: 2005

ISSN: 1358-863X,1477-0377

DOI: 10.1191/1358863x05vm599oa