Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres
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Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes.
In the search for a leishmaniasis vaccine, extensive studies of cutaneous leishmaniasis have been carried out. Investigations in this regard with the visceral form are limited. As an initial step in the identification of the protective molecules, leishmanial antigens extracted from the membranes of Leishmania donovani promastigotes, alone or in association with liposomes, were evaluated for the...
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Outer membrane proteins, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are considered immunodominant antigens for eliciting protective immunity against Vibrio harveyi, the main etiological agent of vibriosis in fish. Cationic antimicrobial peptides (AMPs), such as pleurocidin (PLE), play important roles in activating and recruiting immune cells, thereby contributing to subsequent in...
متن کاملStabilization of a model formalinized protein antigen encapsulated in poly(lactide-co-glycolide)-based microspheres.
A formaldehyde-mediated aggregation pathway (FMAP) has been shown to be primarily responsible for the solid-state aggregation of lyophilized formalinized protein antigens [e.g., tetanus toxoid (TT) and formalinized bovine serum albumin (f-BSA)] in the presence of moisture and physiological temperature. Coincorporation of the formaldehyde-interacting amino acid, histidine, strongly inhibits the ...
متن کاملEncapsulation of Naja –Naja Oxiana Snake venom into Poly (lactide-co-glycolide) microspheres
One small-scale double emulsion technique for incorporation of Naja- Naja oxiana venom into Poly (lactide-co-glycolide) (PLGA) microspheres were developed and optimized. The effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and In vitro release of venom were studied. A stable double emulsion was verified by homogenization method. Slow...
متن کاملModulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheres.
BACKGROUND Biodegradable poly(lactide- co -glycolide) (PLGA) microspheres are a promising carrier for vaccine delivery capable of maturing antigen-presenting cells to stimulate T-cell-mediated immune responses. However, the potential of microspheres to downregulate an allergic response in vivo is unknown. OBJECTIVE The aim of this study was to determine whether microspheres could potentiate D...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1995
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.63.4.1195-1200.1995