منابع مشابه
Adjuvant activity of Mycobacterium leprae.
Mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. Histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of M. leprae and much smaller amounts after the injection of M. tuberculosis.
متن کاملStructure of Mycobacterium leprae.
Introduction : why study structure? Information about the structure of M. leprae may be obtained by microscopy (especially electron miscroscopy) and other physical techniques . There is active development of such techniques , but at present the information they can give about structures as complex as a bac terium is l imited . To obtain a detailed knowledge of the molecular composition and con...
متن کاملActivity of derivatives and analogs of dapsone against Mycobacterium leprae.
Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.
متن کاملActivity of ofloxacin and pefloxacin against Mycobacterium leprae in mice.
The fluorinated quinolones are potent antibacterial compounds active against both gram-negative and gram-positive bacteria (1, 3-5, 11-13). Some are also active against mycobacteria in general (3, 9, 10, 13) and Mycobacterium tuberculosis in particular (1; unpublished observations). In view of the limited number of drugs active against Mycobacterium leprae, it was of interest to test some of th...
متن کاملImmunostimulatory activity of recombinant Mycobacterium bovis BCG that secretes major membrane protein II of Mycobacterium leprae.
We previously demonstrated that major membrane protein II (MMP-II) is one of the immunodominant antigens (Ags) of Mycobacterium leprae capable of activating T cells through Toll-like receptor 2. Based on the observation that Mycobacterium bovis BCG secreting a 30-kDa protein offered better protection against tuberculosis, we constructed a recombinant BCG strain (BCG-SM) that secretes MMP-II to ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1972
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.6.6.909-912.1972