ADJUSTMENT TO ALDOSTERONE OR DESOXYCORTICOSTERONE ACETATE INDUCED SODIUM RETENTION IN PATIENTS WITH ADDISON'S DISEASE *
نویسندگان
چکیده
منابع مشابه
Adjustment to aldosterone or desoxycorticosterone acetate induced sodium retention in patients with Addison's disease.
Long term administration of aldosterone (1) or desoxycorticosterone acetate (DCA) (2) to normal subjects has been shown, in certain instances, to produce continued renal potassium loss but only transient sodium and chloride retention. This adjustment of the renal response to sodium-retaining adrenal steroids has been termed an "escape" (3) from the expected effects of these compounds, and is se...
متن کاملDesoxycorticosterone Acetate
1. Desoxycorticosterone acetate (DCA) and NaCl, in the dosage employed in normal rats, caused renal and cardiac hypertrophy, characteristic changes in the renal tubular epithelium, atrophic changes in the subcapsular zone of the adrenal cortex, and serum electrolyte changes characterized by a rise in sodium and fall in potassium. 2. In rats rendered nephritic with a rabbit anti-rat-kidney serum...
متن کاملRelationship of sodium retention to potassium excretion by the kidney during administration of desoxycorticosterone acetate to dogs.
T HE EFFECT of desoxycorticosterone acetate (DCA) on potassium (K) metabolism has been investigated extensively in man, dog and rat; the characteristic response consists of kaluresis, hypokalemia and metabolic alkalosis. Dependence of these alterations in electrolyte metabolism on an adequate intake of sodium (Na) was recognized by Seldin, Welt and Cort (I). They reported that patients fed a lo...
متن کاملDesoxycorticosterone Acetate and Wound Healing
The effect of desoxycorticosterone acetate (DCA) on the granulation tissue of healing and healed linear laparotomy wounds was studied in young adult male guinea pigs maintained on a complete diet and on a known intake of ascorbic acid. DCA induces the production of an excessive amount of granulation tissue, as evidenced by a relatively great number of fibroblasts and by a larger amount of groun...
متن کاملThe relationship between Aldosterone level and various LV conditions in patients with End-stage renal disease
Background: Aldosterone has been assumed to be implicated in left ventricular hypertrophy (LVH). Preventing the progression of LVH in the early period of end-stage renal disease (ESRD) can increase patient survival. In this study, therefore, we analyzed the relationship between aldosterone level and LVH in ESRD patients who underwent hemodialysis at Fatemeh Zahra Hospital and Imam Khomeini Hosp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1959
ISSN: 0021-9738
DOI: 10.1172/jci103975