Adipose Tissue Plasticity in Catch-Up-Growth Trajectories to Metabolic Syndrome: Hyperplastic Versus Hypertrophic Catch-Up Fat
نویسندگان
چکیده
منابع مشابه
Adipose Tissue Plasticity in Catch-Up–Growth Trajectories to Metabolic Syndrome
In the midt a time when the concept of Syndrome X was being introduced by Reaven (1) to draw attention to the cardiovascular risks associated with insulin resistance and compensatory hyperinsulinemia, Tanner (2) was emphasizing a fundamental property of human growth as a targetseeking function: Children, no less than rockets, have their trajectories, governed by control systems of their genetic...
متن کاملAdipose tissue plasticity during catch-up growth Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: Relevance for muscle-adipose glucose redistribution during catch-up growth
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online...
متن کاملRedistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndrome.
Catch-up growth, a risk factor for later obesity, type 2 diabetes, and cardiovascular diseases, is characterized by hyperinsulinemia and an accelerated rate for recovering fat mass, i.e., catch-up fat. To identify potential mechanisms in the link between hyperinsulinemia and catch-up fat during catch-up growth, we studied the in vivo action of insulin on glucose utilization in skeletal muscle a...
متن کاملAdipose Tissue Plasticity During Catch-Up Fat Driven by Thrifty Metabolism
OBJECTIVE Catch-up growth, a risk factor for later type 2 diabetes, is characterized by hyperinsulinemia, accelerated body-fat recovery (catch-up fat), and enhanced glucose utilization in adipose tissue. Our objective was to characterize the determinants of enhanced glucose utilization in adipose tissue during catch-up fat. RESEARCH DESIGN AND METHODS White adipose tissue morphometry, lipogen...
متن کاملA role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growth.
Catch-up growth is a risk factor for later obesity, type 2 diabetes, and cardiovascular diseases. We show here that after growth arrest by semistarvation, rats refed the same amount of a low-fat diet as controls show 1) lower energy expenditure due to diminished thermogenesis that favors accelerated fat deposition or catch-up fat and 2) normal glucose tolerance but higher plasma insulin after a...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2009
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db09-0290