Adenoviruses as vectors for delivering vaccines to mucosal surfaces
نویسندگان
چکیده
منابع مشابه
Simian adenoviruses as vaccine vectors
Replication incompetent human adenovirus serotype 5 (HAdV-C5) has been extensively used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These vectors infect replicating and nonreplicating cells, have a broad tissue tropism, elicit high immune responses and are easily purified to high titers. However, the utility of HAdV-C5 vectors as potential vaccines is limite...
متن کاملLactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines
Food-grade Lactic Acid Bacteria (LAB) have been safely consumed for centuries by humans in fermented foods. Thus, they are good candidates to develop novel oral vectors, constituting attractive alternatives to attenuated pathogens, for mucosal delivery strategies. Herein, this review summarizes our research, up until now, on the use of LAB as mucosal delivery vectors for therapeutic proteins an...
متن کاملReplicon RNA Viral Vectors as Vaccines
Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein genes and antigens. Administration of replicon RNA vectors has resulted in strong immune responses and generation of neutralizing antibodies in var...
متن کاملRecombinant adenoviruses as expression vectors and as probes for DNA repair in human cells
_________________________________________________________________________________________________ *Correspondence: Dr. Andrew J. Rainbow, Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Tel: (905) 5259140 Ext. 23544 Fax: (905)-522-6066; E-mail: [email protected]
متن کامل-as vaccines and vectors for immune and gene therapy
............................................................................................. 3
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biotechnology
سال: 2000
ISSN: 0168-1656
DOI: 10.1016/s0168-1656(00)00314-x