Adenovirus-mediated gene transfer of rat apolipoprotein B mRNA-editing protein in mice virtually eliminates apolipoprotein B-100 and normal low density lipoprotein production.
نویسندگان
چکیده
منابع مشابه
The association between small dense low density lipoprotein,apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio and coronary artery stenosis
Abstract Background: Recently, small dense low density lipoprotein (sdLDL) has been highlighted as a new risk factor for the coronary artery disease (CAD).Small dense LDLs are believed to be atherogenic since these particles are taken up more easily by arterial wall. They are readily oxidized and have reduced affinity for low density lipoprotein (LDL) receptor and increased affinity...
متن کاملHepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice.
In addition to its role in the uptake of apolipoprotein B (apoB)-containing lipoproteins, apoE promotes hepatic very low density lipoprotein-triglyceride (VLDL-TG) production in animal models. However, it is not known if apoE increases the amount of TG per VLDL particle or the number of VLDL particles secreted. VLDL-apoB production is a measure of the rate of VLDL particle secretion. We determi...
متن کاملthe association between small dense low density lipoprotein,apolipoprotein b, apolipoprotein b/apolipoprotein a1 ratio and coronary artery stenosis
abstract background: recently, small dense low density lipoprotein (sdldl) has been highlighted as a new risk factor for the coronary artery disease (cad).small dense ldls are believed to be atherogenic since these particles are taken up more easily by arterial wall. they are readily oxidized and have reduced affinity for low density lipoprotein (ldl) receptor and increased affinity for arter...
متن کاملComplete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.
OBJECTIVE We addressed the role of the low-density lipoprotein (LDL) receptor in determining clearance rates and production rate (PR) of apolipoprotein B (apoB) in humans. METHODS AND RESULTS Kinetic studies using endogenous labeling of apoB with deuterated leucine were performed in 7 genetically defined patients with homozygous familial hypercholesterolemia (FH) and compared with 4 controls....
متن کاملApolipoprotein B polymorphism and altered apolipoprotein B and low density lipoprotein cholesterol concentrations in Finnish children.
169 oscopy, false positive results are not uncommon with double contrast radiology, and up to 29% of polyps may be missed, although this figure falls to under 10% for polyps over 1 cm in diameter.'3 The presence of diverticular disease makes the diagnosis of associated lesions more difficult,'0 14 some authorities recommending that colonoscopy should be performed in all patients with symptomati...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)43892-6