Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila

Adenosine (Ado) is an important signaling molecule involved in stress responses. Studies mammalian models have shown that Ado regulates mechanisms “danger-sensing” and tissue-protection. Yet, little known about the role of Drosophila . In present study, we observed lower extracellular concentration suppressed expression transporters flies expressing mutant huntingtin protein (mHTT). We altered using genetic tools found overexpression metabolic enzymes, as well suppression receptor (AdoR) (ENTs), were able to minimize mHTT-induced mortality. also identified downstream targets AdoR pathway, modifier mdg4 (Mod(mdg4)) heat-shock 70 (Hsp70), which modulated formation mHTT aggregates. Finally, showed a decrease affects other reactions, including paraquat treatments. Our study provides insights into how responses