Adenosine inhibits epileptiform activity arising in hippocampal area CA3
نویسندگان
چکیده
منابع مشابه
Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures.
Rat hippocampal area CA3 pyramidal cells synchronously discharge in rhythmic bursts of action potentials after acute disinhibition or convulsant treatment in vitro. These burst discharges resemble epileptiform activity, and are of interest because they may shed light on mechanisms underlying limbic seizures. However, few studies have examined CA3 burst discharges in an animal model of epilepsy,...
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Purpose: Our study aimed to investigate the effects of dexmedetomidine on basal synaptic transmission in the rat hippocampus. We also examined dexmedetomidine in an animal epilepsy model, with further investigation into the role of specific antagonists on the alpha-2 adrenoceptors and the imidazoline receptors. Methods: All of the experiments used the CA1 region of hippocampal brain slices prep...
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Although the peptide somatostatin (SST) has been speculated to function in temporal lobe epilepsy, its exact role is unclear, as in vivo studies have suggested both pro- and anticonvulsant properties. We have shown previously that SST has multiple inhibitory cellular actions in the CA1 region of the hippocampus, suggesting that in this region SST should have antiepileptic actions. To directly a...
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Pilocarpine, a muscarinic agonist, produces status epilepticus that is associated with the later development of chronic recurrent seizures. When applied to rat hippocampal slices, pilocarpine (10 microM) produced brief (<200 ms) epileptiform discharges that resembled interictal activity that occurs between seizures, as well as more prolonged synchronous neuronal activation that lasted seconds (...
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lthough Zn 2 is contained in large amounts in the synaptic terminals of hippocampal mossy fibers (MFs), its physiological role in synaptic transmission is poorly understood. By using the newly developed high-sensitivity Zn 2 indicator ZnAF-2, the spatiotemporal dynamics of Zn 2 was monitored in rat hippocampal slices. When high-frequency stimulation was delivered to the MFs, the concentration o...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1986
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1986.tb14587.x