Adenosine influences myeloid cells to inhibit aeroallergen sensitization

Adenosine influences myeloid cells to inhibit aeroallergen sensitization.

Agonists of adenosine A2A receptors (A2ARs) suppress the activation of most immune cells and reduce acute inflammatory responses. Asthma is characterized by sensitization in response to initial allergen exposure and by airway hyperreactivity in response to allergen rechallenge. We sought to determine if A2AR activation with CGS-21680 (CGS) is more effective when CGS is administered during sensi...

Aeroallergen sensitization influences quality of life and comorbidities in patients with nasal polyposis

BACKGROUND Nasal polyposis (NP) is a chronic inflammatory disease of unknown etiology that impairs quality of life (QoL). The role of atopy in NP is not established. The aim of this study was to describe the clinical characteristics and QoL in a broad sample of patients with NP and to evaluate the influence of allergy on this disease. METHODS A multicenter, observational, cross-sectional stu...

Aeroallergen Sensitization in Wheezing Children From Rosario, Argentina

BACKGROUND Wheezing is a highly frequent symptom in infants and children. Its major causes are respiratory infections and bronchial asthma. In this context, allergen sensitization plays an important role, and it can be detected by a skin prick test, a safe and effective technique that can be easily performed on any age-group. To assess the prevalence of aeroallergen sensitization in a pediatric...

Aeroallergen-Induced Th2 Inflammation Endogenous and Exogenous IL-6 Inhibit

High prevalence of aeroallergen sensitization among infants of atopic parents.

OBJECTIVE To present methodology to identify atopic parents and determine the prevalence of sensitization to 15 aeroallergens in their infant offspring. STUDY DESIGN A birth cohort of infants was identified from birth records; an infant was enrolled if 1 of the parents reported allergy respiratory symptoms and had a positive skin prick test (SPT) to a common aeroallergen. At age 1 year, these...