Adenosine and dihydropyridines: interactions in rat brain
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منابع مشابه
Adenosine Receptor from Rat Brain Membranes
A1 adenosine receptors from rat brain membranes were solubilized with the zwitterionic detergent 3-[3-( cholamidopropyl)dimeth ylammonio ]-1-propanesulfonate. The solubilized receptors retained all the characteristics of membrane-bound A1 adenosine receptors. A high and a low agonist affinity state for the radiolabelled agonist (R)-N'-eHJphenylisopropyladenosine((JH]PJA) with Kn values of 0.3 a...
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Since adenosine is present in normal brain tissue and cerebrosipinal fluid and since it dilates the pial vessels, it is possible that adenosine, in addition to H-+, is also a mediator of the metabolic regulation of cerebral blood flow. Evidence supporting this hypothesis was obtained under various experimental conditions characterized by achange in brain oxygen supply. The brain was frozen in...
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1. The effect of the adenosine A(2) receptor (AdoA(2)R) agonist N(6)-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)-ethyl]adenosine (DPMA) on adenosine A(1) receptor (AdoA(1)R)-mediated negative inotropic responses was investigated in rat heart. 2. Hearts from male Wistar rats (250-350 g) were perfused with Krebs'-Henseleit solution at constant flow in non-recirculating Langendorff mode. Hearts we...
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The binding characteristics of [3H]nitrobenzylthioinosine ([3H]NBI) to rat brain membrane preparations was examined, and the autoradiographic distribution of this ligand in brain sections was compared with the immunohistochemical localization of adenosine deaminase (ADA). It was found that [3H]NBI labels sites for which adenosine has far higher affinity than do other nucleosides, that these sit...
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2. The nuclei in vitro incorporate [2-14C]glycine and [1-14C]valine into nuclear protein and [6-14C]orotic acid and [8-14C]adenine into nucleic acids. 3. Anoxia and 2,4-dinitrophenol inhibit the incorporation of the radioactive precursors into nuclear proteins and nucleic acids. Chlorpromazine inhibits the incorporation of valine, but has no effect on the incorporation of orotic acid. 4. The sp...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)32940-3