منابع مشابه
DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma
Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer therapy trials in human lung cancer patients. Recently, we identified DOK2 as a lung adenocarcinoma tumor suppressor gene. Here we show that genomic loss of DOK2 is associa...
متن کاملEGFR-Mutant Lung Adenocarcinoma Mimicking a Pneumonia
PET-CT scan has demonstrated to be very effective in lung cancer diagnosis and staging, but lung cancer has multiple ways of presentation, which can lead to an error in diagnosis imaging and a delay on the beginning of specific treatment. We present a case of a 77-year-old man with an initial PET-CT scan showing high 18F-FDG intake, suggesting a bilateral pneumonia, who was finally diagnosed of...
متن کاملAfatinib monotherapy in EGFR-mutant lung adenocarcinoma.
In a prospective randomised phase 3 clinical trial, investigators compared afatinib with the combination of pemetrexed and cisplatin as initial therapy for patients with advanced lung adenocarcinoma harbouring activating EGFR mutations. They reported that progression-free survival was signifi cantly longer with afatinib than with pemetrexed–cisplatin (median 11·1 months vs 6·9 months; hazard ra...
متن کاملCharacterizing Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in an EGFR Mutant Lung Adenocarcinoma Cell Line
Traditional treatments for lung adenocarcinomas do not produce impressive improvements in patient health. Newly developed biologically-based treatments exploit sensitivity to tyrosine kinase inhibitors (TKIs) conferred by somatic mutations in the epidermal growth factor receptor (EGFR) found in certain lung adenocarcinomas. However, almost every patient acquires resistance to TKI treatment, and...
متن کاملEpidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma*
Genetic mutations in tumor cells cause several unique metabolic phenotypes that are critical for cancer cell proliferation. Mutations in the tyrosine kinase epidermal growth factor receptor (EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD). However, the linkage between oncogenic mutated EGFR and cancer cell metabolism has not yet been clearly elucidated. Here we show that EGFR sign...
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ژورنال
عنوان ژورنال: Jurnal Kedokteran Syiah Kuala
سال: 2018
ISSN: 2550-0112,1412-1026
DOI: 10.24815/jks.v18i1.11216