Additive manufacturing of Bio-inspired ceramic bone Scaffolds: Structural Design, mechanical properties and biocompatibility

نویسندگان

چکیده

• The design method based on Voronoi was proposed to mimic the characteristics of cancellous bone in human body. Ceramic Digital light processing (DLP) adopted satisfy forming requirements irregular scaffolds. compressive strength scaffolds can be increased by 30% through regulation irregularity. Cell experiments confirmed that structural changes also had influence biocompatibility Ideal require good and moderate mechanical properties, so as promote proliferation differentiation osteoblast cells, achieve repair. Inspired porous structure bone, 15 groups with variable irregularity (Ir1-5) porosity (35.53–61.75%) were designed fabricated ceramic digital using 20 wt% hydroxyapatite doped zirconia matrix material. effects parameters material properties studied. shrinkage test results showed density mainly affected porosity. Ir2 Ir3 better behaviors, could regulating All comparable bone. effect cell proliferation, differentiation, mineralization most evident at early stage implantation. Meanwhile, variation consistent properties. This study proved a bio-inspired scaffold excellent comprehensive obtained reasonable design.

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ژورنال

عنوان ژورنال: Materials & Design

سال: 2022

ISSN: ['1873-4197', '0264-1275']

DOI: https://doi.org/10.1016/j.matdes.2022.110610