Addison's disease without pigmentation

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Addison's disease without pigmentation.

Introduction It has been said that pigmentation of the skin is the most distinctive feature of Addison's disease (British Medical Journal, 1963) and that no other clinical feature is as useful diagnostically (Dunlop, 1963). Four cases are presented where no pigmentation was found. The difficulties in diagnosis are discussed and it is suggested that Addison's disease without pigmentation is comm...

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Appendicectomy Complicated by Addisons Disease

requiring admission to ICU. Case report: A 33 year old male presented with a fifteen-hour history of vomiting, diarrhoea, and lower abdominal pain one week after a holiday in Portugal. He had no significant past medical history. On examination he had a tanned appearance, and was tender with guarding and rebound in the right iliac fossa. Rovsing’s sign was positive. He proceeded to theatre where...

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Crisis following Corticotrophin in Addison's Disease without Pigmentation.

dialysis produced an effective biochemical adjustment and ultrafiltration of excess fluid. A chest X-ray subsequent to this dialysis demonstrated no evidence of pulmonary cedema. Diuresis commenced I4 days after the ingestion of mercuric chloride and an uneventful recovery ensued. Discussion Pulmonary cedema complicating acute renal failure is subsequent to hypervolemia produced by overhydratio...

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Human skin pigmentation, migration and disease susceptibility.

Human skin pigmentation evolved as a compromise between the conflicting physiological demands of protection against the deleterious effects of ultraviolet radiation (UVR) and photosynthesis of UVB-dependent vitamin D(3). Living under high UVR near the equator, ancestral Homo sapiens had skin rich in protective eumelanin. Dispersals outside of the tropics were associated with positive selection ...

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Peutz-Jeghers syndrome without mucocutaneous pigmentation: a case report

Peutz-Jeghers syndrome is a rare condition characterized by mucocutaneous pigmentation, polyposis and an increased cancer risk at a number of gastrointestinal and extra intestinal organs. We present a patient with a history of gastrointestinal bleeding with no mucocutaneous pigmentation. Upper and lower gastrointestinal endoscopy revealed multiple polyps located in the deuodenum and colon. Hist...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1973

ISSN: 0032-5473

DOI: 10.1136/pgmj.49.571.305