Adding a piece to the LTP jigsaw

A new piece in the kinetochore jigsaw puzzle

In eukaryotic cell division, the kinetochore mediates chromosome attachment to spindle microtubules and acts as a scaffold for signaling pathways, ensuring the accuracy of chromosome segregation. The architecture of the kinetochore underlies its function in mitosis. In this issue, Hornung et al. (2014. J. Cell Biol. http://dx.doi.org/201403081) identify an unexpected linkage between the inner a...

A key piece of the jigsaw for improving world health.

37. TropIKA [Internet site]. Available from: http://www.tropika.net/ [accessed 29 June 2009]. 38. Suber P. India’s CSIR asks its labs to adopt OA mandates. Open Access News, 9 February 2009. Available from:http://www.earlham.edu/~peters/ fos/2009/02/india-csir-asks-its-labs-to-adopt-oa.html [accessed 29 June 2009]. 39. Open access self-archiving policy. Pretoria: University of Pretoria. Availab...

The dad deficit the missing piece of the maternity jigsaw.

Capturing VCP: Another Molecular Piece in the ALS Jigsaw Puzzle

TDP-43 mislocalization and aggregation are implicated in the pathogenesis of ALS and FTLD-U. Valosin containing protein (VCP) mutations also lead to TDP-43 deposition, resulting in Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD). In this issue of Neuron, Johnson et al. used whole-exome capture to identify VCP mutations in familial ALS. This extends the VCP phenotype...

Clinical risk management: one piece of the quality jigsaw.