Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics
نویسندگان
چکیده
منابع مشابه
Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells.
Evidence for the cancer stem cell model was first demonstrated in xenotransplanted blood and bone marrow samples from patients with acute myeloid leukemia (AML) almost two decades ago, supporting the concept that a rare clonal and mutated leukemic stem cell (LSC) population is sufficient to drive leukemic growth. The inability to eliminate LSCs with conventional therapies is thought to be the p...
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Acute myeloid leukemia remains a difficult disease to cure and novel therapeutic approaches are needed. To this end, we developed CD123 chimeric antigen receptor (CAR) redirected T cells which exhibited potent antileukemic activity. We discuss what we learned during the development of CD123 CARs and future directions for this immunotherapy.
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Abstract Background Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. The objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune ph...
متن کاملPeripheral blood stem cells in acute myeloid leukemia: biology and clinical applications.
linical application of circulating stem cells for autologous transplantation is steadily expanding. 1 It has become increasingly clear that mobilized peripheral blood progenitor cells (PBSC) induce faster hematopoietic recovery, fewer febrile days, lower transfusion requirement and shorter hospitalization than bone marrow (BM)-derived cells. 2,3 More recently, rapid and sustained engraftment ha...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Age and acute myeloid leukemia
We conducted a retrospective analysis of 968 adults with acute myeloid leukemia (AML) on 5 recent Southwest Oncology Group trials to understand how the nature of AML changes with age. Older study patients with AML presented with poorer performance status, lower white blood cell counts, and a lower percentage of marrow blasts. Multidrug resistance was found in 33% of AMLs in patients younger tha...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2020
ISSN: 2234-943X
DOI: 10.3389/fonc.2020.599933