Acute Kidney Injury–Induced Systemic Inflammation and Risk of Kidney Cancer Formation

Abstract In this issue of Cancer Research, Zhou and colleagues investigate the role acute kidney injury (AKI) AKI-associated systemic inflammation in development cancer. They demonstrate a positive association between formation clear-cell renal cell carcinoma AKI induced by ischemia-reperfusion genetically modified mice. parallel with emergence tumors, mice ischemic develop associated tissue infiltration neutrophils fibroblasts upregulated expression several inflammatory factors, CXCL1 displaying highest levels upregulation. Accordingly, blockade CXCL1-mediated signaling inhibited tumors subjected to injury. The study provides evidence for new experimental approach prevent reduce cancer incidence through modulation AKI-induced response using inhibitors CXC/CXCR2 axis. As continues increase, treatment strategies devastating disease are urgently needed. provide preclinical proof concept therapeutic strategy address an unmet need difficult treat disease. See related article et al., p. 2690