Acute kidney injury and hepatorenal syndrome in cirrhosis

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Acute kidney injury and hepatorenal syndrome in cirrhosis.

Cirrhosis is the eighth leading cause of "years of lost life" in the United States and accounts for approximately 1% to 2% of all deaths in Europe. Patients with cirrhosis have a high risk of developing acute kidney injury. The clinical characteristics of hepatorenal syndrome (HRS) are similar to prerenal uremia, but the condition does not respond to volume expansion. HRS type 1 is rapidly prog...

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Prognosis of Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis: A Prospective Cohort Study

Background/Aims. Acute kidney injury is a common problem for patients with cirrhosis and is associated with poor survival. We aimed to examine the association between type of acute kidney injury and 90-day mortality. Methods. Prospective cohort study at a major US liver transplant center. A nephrologist's review of the urinary sediment was used in conjunction with the 2007 Ascites Club Criteria...

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Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome

Renal dysfunction is a common complication of liver cirrhosis and of utmost clinical and prognostic relevance. Patients with cirrhosis are more prone to developing acute kidney injury (AKI) than the non-cirrhotic population. Pre-renal AKI, the hepatorenal syndrome type of AKI (HRS-AKI, formerly known as 'type 1') and acute tubular necrosis represent the most common causes of AKI in cirrhosis. C...

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Hepatorenal syndrome in cirrhosis: pathogenesis and treatment.

Hepatorenal syndrome (HRS) is a major complication in cirrhosis, with an annual incidence in patients with ascites of approximately 8%.1 It develops at the latest phase of the disease and, although initially considered without impact in prognosis (patients would die with and not by the renal failure), there is now evidence that it is an important determinant in survival. There are more reviews ...

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Biomarkers in Acute Kidney Injury in Cirrhosis

Cirrhosis is a major contributor to the burden of disease in society, and much of the morbidity and mortality associated with cirrhosis is due to the complications of portal hypertension. Acute kidney injury (AKI) is a frequent complication in patients with cirrhosis, occurring in up to 20 percent of hospitalized patients (1). Despite the high rate of AKI in this patient population, there is of...

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ژورنال

عنوان ژورنال: Journal of Gastroenterology and Hepatology

سال: 2015

ISSN: 0815-9319

DOI: 10.1111/jgh.12709