Acute and definitive renal failure in progressive multiple myeloma treated with recombinant interferon alpha-2a: Report on two patients
نویسندگان
چکیده
منابع مشابه
The Effect of Heat Shock on Production of Recombinant Human Interferon Alpha 2a (rhIFN α -2a) by Escherichia coli
Recombinant human interferon alpha 2a (rhIFN α -2a) production and cell growth were monitored in a set of genetically modified E. coli strains (MSD1519, MSD1520, MSD 1521, MSD 1522, MSD 1523) producing rhIFN α -2a. The growth was followed at OD 600 nm, changes in cell physiology were detected by pyrolysis mass spectrometry (PyMS) of cell biomass and recombinant protein production was determined...
متن کاملMultiple myeloma presented as acute renal failure
Multiple myeloma (MM) is a plasma cell dyscrasia and it most often occurs in old age adults. The mean age of the patients at diagnosis is 66 years old and only few percent of patients are younger than 40 years old (1,2). At the time of diagnosis, about 3% of MM patients have no M-protein in their serum or urine, based on immunofixation method (1-3). Approximately 50% of MM patients have at leas...
متن کاملMultiple myeloma presenting as acute renal failure.
CASE PRESENTATION A 68-year-old African American woman presented to the emergency department after routine blood work with her primary care physician revealed abnormal renal function studies. Six months prior to admission, she began to have nonspecifi c pain in her back, knees, and feet. Degenerative osteoarthritis was diagnosed, and she was treated with conservative measures including physical...
متن کاملIncidence of response and long-term follow-up in patients with hairy cell leukemia treated with recombinant interferon alpha-2A.
Thirty-five evaluable patients with hairy cell leukemia (HCL) were treated with recombinant interferon alfa-2a (rIFN-alpha 2a), given at a dose of 3 X 10(6) units (U) intramuscularly (IM) daily for 6 months followed by 3 X 10(6) U IM three times a week for an additional 18 months in a single institution study. All treatment was stopped after 24 months. Sixty-nine percent of patients achieved a ...
متن کاملAcute renal failure with polyarteritis nodosa and multiple myeloma.
A patient who presented with acute renal failure due to renal cortical necrosis is described. Renal biopsy showed cortical infarction and angiography demonstrated aneurysms in the renal, splenic and hepatic circulations. Concurrently he was found to have an IgA kappa paraprotein with bone marrow changes diagnostic of multiple myeloma. He was treated with haemodialysis, immunosuppressive drugs a...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1992
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.2830410420