ACTIVITY MODULATION OF VARIOUS NITRIC OXIDE SYNTASES AS AN APPROACH TO ENDOTHELIAL DYSFUNCTION THERAPY
نویسندگان
چکیده
Nitric oxide as a therapeutic approach to the treatment of cardiovascular diseases attracted attention researchers at end 19th century. As vasodilator, nitric may be unique agent for hypertension and, result, renal failure and left ventricular hypertrophy. The aim article is analyze literature data on possible ways modulating activity various synthases an endothelial dysfunction. Materials methods. When searching materials writing review article, such abstract databases PubMed, Google Scholar, e-Library, etc., were used. search was carried out publications period from 1990 2021. following words phrases chosen parameters selection: oxide; NO synthase; dysfunction; synthase activator; inhibitor. Results. presents history discovery its biological role, process biosynthesis, well isoforms synthesizing enzymes (NOS): neuronal – nNOS, eNOS inducible iNOS, their role in normal pathological physiology. NOS uncoupling (its molecular mechanisms) has been considered basis examples pharmacological correction (BH 4 , arginase inhibitors, statins, resveratrol) are presented. In addition, activators (calcium dobesilate, cavNOxin, some transcription activators), non-selective (L-NMMA, 1-NNA, L-NAME, ADMA, 546C88, VAS203) selective (L-NIO, 7-nitroindazole, aminoguanidine, L-NIL, GW273629, GW274150, cavtratin) inhibitors synthasehave described. Conclusion. continue promising targets development agents that modulate correct pathologies. approach, modulation can implemented treat dysfunction, which cause complications many diseases.
منابع مشابه
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ژورنال
عنوان ژورنال: Farmaciâ i Farmakologiâ (Pâtigorsk)
سال: 2022
ISSN: ['2307-9266', '2413-2241']
DOI: https://doi.org/10.19163/2307-9266-2022-10-2-130-153