Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation
نویسندگان
چکیده
منابع مشابه
Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
Maintaining a proper balance between excitation and inhibition is essential for the functioning of neuronal networks. However, little is known about the mechanisms through which excitatory activity can affect inhibitory synapse plasticity. Here we used tagged gephyrin, one of the main scaffolding proteins of the postsynaptic density at GABAergic synapses, to monitor the activity-dependent adapt...
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Synaptic plasticity relies on the rapid changes in neurotransmitter receptor number at postsynaptic sites. Using superresolution photoactivatable localization microscopy imaging and quantum dot-based single-particle tracking in rat hippocampal cultured neurons, we investigated whether the phosphorylation status of the main scaffolding protein gephyrin influenced the organization of the gephyrin...
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Postsynaptic scaffolding proteins ensure efficient neurotransmission by anchoring receptors and signaling molecules in synapse-specific subcellular domains. In turn, posttranslational modifications of scaffolding proteins contribute to synaptic plasticity by remodeling the postsynaptic apparatus. Though these mechanisms are operant in glutamatergic synapses, little is known about regulation of ...
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ATP-dependent chromatin remodeling complexes such as INO80 have been implicated in checkpoint regulation in response to DNA damage. However, how chromatin remodeling complexes regulate DNA damage checkpoints remain unclear. Here, we identified a mechanism of regulating checkpoint effector kinase Rad53 through a direct interaction with the INO80 chromatin remodeling complex. Rad53 is a key check...
متن کاملCorrection for Huang et al., Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
NEUROSCIENCE Correction for “Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development,” by Huiqian Huang, Xiaochen Lin, Zhuoyi Liang, Teng Zhao, Shengwang Du, Michael M. T. Loy, Kwok-On Lai, Amy K. Y. Fu, and Nancy Y. Ip, which was first published July 31, 2017; 10.1073/pnas.1708240114 (Proc Natl Acad Sci USA 114:E6992–E7001). The authors note that Fig...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1411170112