Active Notch signaling is required for arm regeneration in a brittle star
نویسندگان
چکیده
منابع مشابه
Expression of skeletogenic genes during arm regeneration in the brittle star Amphiura filiformis☆
The brittle star Amphiura filiformis, which regenerates its arms post autotomy, is emerging as a useful model for studying the molecular underpinnings of regeneration, aided by the recent availability of some molecular resources. During regeneration a blastema initially is formed distally to the amputation site, and then a rapid rebuild is obtained by adding metameric units, which will eventual...
متن کاملHabitat Distribution and Comparison of Brittle Star (Echinodermata: Ophiuroidea) Arm Regeneration on Moorea, French Polynesia
Autotomy and regeneration are widespread in many groups of invertebrates and vertebrates, such as annelids, crustaceans, amphibians, and reptiles. Regeneration is common in all classes of Echinodermata and prevalent in ophiuroid brittle stars. Moorea, French Polynesia was surveyed for species of brittle stars living on coastal areas of the island in different habitats. Ophiuroid populations wer...
متن کاملRumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28 degrees C-30 degrees C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18 degrees C only a mild Notch phenotype is evident. In vivo analyses reveal that the target of Rumi is the extracellular domain of...
متن کاملLunatic Fringe-mediated Notch signaling is required for lung alveogenesis.
Distal lung development occurs through coordinated induction of myofibroblasts, epithelial cells, and capillaries. Lunatic Fringe (Lfng) is a beta(1-3) N-acetylglucosamine transferase that modifies Notch receptors to facilitate their activation by Delta-like (Dll1/4) ligands. Lfng is expressed in the distal lung during saccular development, and deletion of this gene impairs myofibroblast differ...
متن کاملNotch Signaling is Required for Osteoclast Differentiation and Function
Introduction Osteoclasts are multinucleated giant cells responsible for the resorption of bone. As such, they are a critical component along with bone-forming osteoblasts and bone-regulating osteocytes in the process of bone remodeling. For this reason, osteoclasts are an attractive target in instances where increased bone mass is desired. In particular, anti-resorptive agents, which are chemic...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0232981