ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS
نویسندگان
چکیده
منابع مشابه
Active Immunization of Guinea Pigs with the Virus of Equine Encephalomyelitis
A study was undertaken on the effect in vivo, in the guinea pig, of equine encephalomyelitis virus antiserum upon the antigenic response to active, as compared with that to formolized, inactive virus. It was found that when animals were given subcutaneously a proper amount of hyperimmune serum 1 hour before inoculation, in the subcutis, of either active or of inactive virus, no immunity was ind...
متن کاملActive Immunization of Guinea Pigs with the Virus of Equine Encephalomyelitis I I . Immunization with Formolized Virus
The virus of equine encephalomyelitis appears in the blood in the natural infection of horses before the appearance of clinical symptoms, and epidemiological and experimental findings favor the view that it is disseminated by insect vectors (1), especially the mosquito (2-4). Were immunization attempted by the use of active virus, the danger might arise of bringing about either lethal encephali...
متن کاملActive Immunication of Guinea Pigs with the Virus of Equine Encephalomyelitis
Active Eastern or Western equine encephalomyelitis virus in three forms,-chemically untreated but simply passaged through series of mice; adsorbed on alumina Gel C, and precipitated by tannin,-yielded practically the same results when employed for the immunization of guinea pigs. The virus is not inactivated by the process of adsorption or precipitation : guinea pigs and mice inoculated in the ...
متن کاملACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS I. QUAI~TITATIW EXPERIMENTS WITH VARIOUS PREPARATIONS OF AcTIvE VIRUS
The object of this paper is to describe attempts at determining the minimal quantity of the virus of equine encephMomyelitis needed for producing resistance to experimental infection of guinea pigs by way of the nose, skin, and brain. With this known, a basis has been constructed for comparing the immunizing capacity of virus preparations. The Eastern and Western strains were employed in this s...
متن کاملThe Mechanism of Active Cerebral Immunity to Equine Encephalomyelitis Virus
The fate of W.E.E. virus has been followed in the brains of mice vaccinated to such an extent that they failed to resist a large intracerebral challenge dose of a viral variant with a rapid rate of multiplication but were fully protected against a similar amount of a "slow" strain. The growth rate of the "fast" variant in vaccinated animals paralleled that in non-vaccinated ones at a slightly l...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1936
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.64.2.217