Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.
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چکیده
منابع مشابه
Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.
Trichloroethylene (TCE) and related hydrocarbons constitute an important class of environmental pollutants whose adverse effects on liver, kidney, and other tissues may, in part, be mediated by peroxisome proliferator-activated receptors (PPARs), ligand-activated transcription factors belonging to the steroid receptor superfamily. Activation of PPAR induces a dramatic proliferation of peroxisom...
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Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-activated nuclear hormone receptor superfamily of transcription factors that includes receptors for steroids, thyroid hormone, retinoic acid, and vitamin D. Upon activation in the cytoplasm, PPARs heterodimerize with retinoid X receptors (RXR) and form a complex that translocates to the nucleus and regulates gene expr...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1998
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.98106s4983