Activation of peroxisome proliferator-activated receptor γ inhibits vascular calcification by upregulating Klotho

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Activation of peroxisome proliferator-activated receptor γ inhibits vascular calcification by upregulating Klotho

Cardiovascular diseases are common in patients with chronic kidney disease. One of the key symptoms is the calcification of the vascular smooth muscle cells (VSMCs), which is induced by dysregulated mineral metabolism with high circulating levels of inorganic phosphate (Pi) and calcium. Klotho, which was originally identified as an aging suppressor gene, has been shown to be associated with vas...

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ژورنال

عنوان ژورنال: Experimental and Therapeutic Medicine

سال: 2016

ISSN: 1792-0981,1792-1015

DOI: 10.3892/etm.2016.3996