Activation of Muscle Fructose 1,6-Diphosphatase by Creatine Phosphate and Citrate
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منابع مشابه
The dissociation of D-fructose 1,6-diphosphatase by adenosine 5'-phosphate.
Adenosine 5’-monophosphate, an inhibitor of the D-fructose 1,6diphosphatase isolated from Candida utilis, induces a specific dissociation of this enzyme at pH 9.2. On the basis of sucrose density gradient centrifugation and gel filtration on Sephadex G-100, it may be concluded that the molecule has dissociated into subunits having one-half the molecular weight of the native enzyme. The dissocia...
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The catalytic activity of rabbit liver fructose diphosphatase is enhanced more than fourfold by treatment with coenzyme A or acyl carrier protein. Other sulfhydryl compounds, such as glutathione or cysteine, are without effect. Activation is reversed by reduced glutathione or cysteine, indicating that the enzyme and activator are linked by disulfide bridges. The activated enzyme derivative can ...
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1. The present study extends the finding of Krebs & Woodford (1965) that muscle fructose diphosphatase is more sensitive to AMP inhibition than liver fructose diphosphatase. 2. Hen breast fructose diphosphatase has a K(i) for AMP of 0.1mum; the plot of percentage inhibition is non-sigmoid and the reciprocal plot of activity against AMP concentration is sometimes linear. 3. Percentage inhibition...
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Purified bovine hepatic fructose-1,6-diphosphatase, which exhibits maximal activity at neutral pH, is competitively inhibited by several analogs of its substrate, fructose 1,6-diphosphate. These include glucose 1,6-diphosphate (Ki = 9.4 X 10(-5) M), hexitol 1,6-diphosphate (Ki = 2.3 X 10(-4) M), and 2,5-anhydro-D-mannitol 1,6-diphosphate (Ki = 3.3 X 10(-8) M), and 2,5-anhydro-D-glucitol 1,6-dip...
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Fructose-1,6-diphosphatase was derepressed in Saccharomyces cerevisiae by incubation in media containing non-sugar carbon sources. Addition of glucose to a derepressed culture led to a rapid loss of the measurable activity of the enzyme. Fructose and mannose also produced inactivation, but 2-deoxyglucose was ineffective. Experiments with cycloheximide indicated that the inactivation does not re...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)44381-0