Activation of complement by Neisseria meningitidis
نویسندگان
چکیده
منابع مشابه
Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide.
Fulminant meningococcal sepsis has been termed the prototypical lipopolysaccharide (LPS)-mediated gram-negative septic shock. Systemic inflammation by activated complement and cytokines is important in the pathogenesis of this disease. We investigated the involvement of meningococcal LPS in complement activation, complement-dependent inflammatory effects, and cytokine or chemokine production. W...
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The importance of the complement system in host defense against systemic infection caused by neisseriae is emphasized by a number of clinical observations documenting the importance of antibody-dependent, complement-mediated serum bactericidal activity in protection from systemic meningococcal disease (17) and the well-recognized association between the resistance of gonococci to complement-dep...
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Mannose-binding lectin (MBL) is a serum protein that has been demonstrated to activate the classical complement pathway and to function directly as an opsonin. Although MBL deficiency is associated with a common opsonic defect and a predisposition to infection, the role of the protein in bacterial infection remains unclear. We have investigated MBL binding to Neisseria meningitidis serogroup B1...
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The capacity for different lipo-oligosaccharide (LOS) sialylation patterns of Neisseria meningitidis serogroup C to influence the binding and function of the innate humoral component, mannose-binding lectin (MBL), was investigated. By use of flow cytometry and immunogold electron microscopy, a clinical isolate with reduced endogenous LOS sialylation was found to bind more MBL than did strains w...
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Biofilm formation by the human pathogen Neisseria meningitidis was analyzed. Biofilm-forming meningococcal strains were identified and quantitated by crystal violet staining. Laser scanning confocal microscopy of the meningococcal biofilm revealed variable layers up to 90 microm in thickness. A total of 39 meningococcal isolates were studied; 23 were nasopharyngeal-carriage isolates, and 16 wer...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1981
ISSN: 0378-1097
DOI: 10.1016/0378-1097(81)90037-9