Activation and signaling of the p38 MAP kinase pathway
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چکیده
منابع مشابه
Synthesis and Evaluation of Pyridinyltriazoles as Inhibitors of p38 MAP Kinase
Objective(s) Inhibitors of p38 MAP kinase are considered as suitable target in the treatment of inflammatory diseases such as rheumatoid arthritis and bowel inflammatory diseases. The development of 5-alkylthio-1-aryl-2-(4-pyridinyl) triazoles as inhibitors of p38 MAP kinase is described. These are analogues of 4- pyridinyl imidazole p38 MAP kinase inhibitor reported by Merck Research Laborator...
متن کاملActivation of p38 MAP kinase pathway by erythropoietin and interleukin-3.
Activation of p38 MAP kinase (p38) as well as JNK/SAPK has been described as being induced by a variety of environmental stresses such as osmotic shock, ultraviolet radiation, and heat shock, or the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 (IL-1). We found that the hematopoietic cytokines erythropoietin (Epo) and IL-3, which regulate growth and differentiation of ...
متن کاملRAPID COMMUNICATION Activation of p38 MAP Kinase Pathway by Erythropoietin and Interleukin-3
Activation of p38 MAP kinase (p38) as well as JNK/SAPK ally be activated by the upstream kinase MKK3 or MKK6. has been described as being induced by a variety of environHowever, in vitro kinase assays in the immunoprecipitates mental stresses such as osmotic shock, ultraviolet radiation, with anti-MKK6 antibody and anti-phosphorylated MKK3/ and heat shock, or the proinflammatory cytokines tumor...
متن کاملThe SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans
Gq is a heterotrimeric G protein that is widely expressed in neurons and regulates neuronal activity. To identify pathways regulating neuronal Gq signaling, we performed a forward genetic screen in Caenorhabditis elegans for suppressors of activated Gq. One of the suppressors is an allele of sek-1, which encodes a mitogen-activated protein kinase kinase (MAPKK) in the p38 MAPK pathway. Here, we...
متن کاملRole of p38 Map Kinase in Type I Interferon Signaling*
From the ‡Robert H. Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, the §Division of Cell & Molecular Biology, Toronto Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario M5S3E2, Canada, the ¶B...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2005
ISSN: 1001-0602,1748-7838
DOI: 10.1038/sj.cr.7290257