منابع مشابه
Activating actin
The sound of one foot walking ells often extend pseudopodia to migrate, but it has been difficult to characterize this process biochemically because intact pseudopodia could not be isolated from cell bodies. Now, on page 725, Cho and Klemke describe a clever method for purifying pseudopodia that have been induced to grow or retract, and identify a signaling complex whose assembly and disassembl...
متن کاملThe Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton.
Arf family GTP-binding proteins are best characterized as regulators of membrane traffic, but recent studies indicate an additional role in cytoskeletal organization. An Arf GTPase-activating protein of the centaurin beta family, ASAP1 (also known as centaurin beta4), binds Arf and two other known regulators of the actin cytoskeleton, the tyrosine kinase Src and phosphatidylinositol 4,5-bisphos...
متن کاملOptogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase
Erythropoietin-producing hepatocellular (Eph) receptors regulate a wide array of developmental processes by responding to cell-cell contacts. EphB2 is well-expressed in the brain and known to be important for dendritic spine development, as well as for the maintenance of the synapses, although the mechanisms of these functions have not been fully understood. Here we studied EphB2's functions in...
متن کاملRas GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans.
Aspergillus nidulans gapA1, a mutation leading to compact, fluffy colonies and delayed polarity establishment, maps to a gene encoding a Ras GTPase-activating protein. Domain organization and phylogenetic analyses strongly indicate that GapA regulates one or more "true" Ras proteins. A gapADelta strain is viable. gapA colonies are more compact than gapA1 colonies and show reduced conidiation. g...
متن کاملPLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.
Cells migrate by directing Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42) activities and by polymerizing actin toward the leading edge of the cell. Previous studies have proposed that this polarization process requires a local positive feedback in the leading edge involving Rac small GTPase and actin polymerization with PI3K likely playing a coord...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1564iti4