Action of Metiamide on the Lower Esophageal Sphincter
نویسندگان
چکیده
منابع مشابه
Mechanics of sphincter action. Studies on the lower esophageal sphincter.
The purpose of this study was to evaluate the mechanical factors involved in the genesis of lower esophageal sphincter pressure. We determined the relationship between intraluminal pressure and inside diameter, estimated the ratio between the wall thickness to inside radius, and calculated the tension in the wall of the lower esophageal sphincter as a function of the inside diameter. Various de...
متن کاملMechanism of action of pentagastrin on the lower esophageal sphincter.
The effects of pentagastrin on lower esophageal sphincter (LES) pressure has been studied in trained, unanesthetized dogs. LES pressure was monitored by an infusion manometric technique. Increasing doses of pentagastrin up to 3 mug/kg given as an i.v. bolus resulted in increasing rises in LES pressure; larger doses resulted in a lesser effect of shorter duration. Increasing i.v. boluses of meth...
متن کاملPharmacologic identification of the lower esophageal sphincter.
The distal 2/3 of the opossum esophagus contains only smooth muscle. Manometry shows that the most distal 1-2 cm is the lower esophageal sphincter. We used a variety of agonists to seek differences between circular muscle from the sphincteric segment and more rostral levels. Isometric contractions of strips from the distal 6 cm were recorded in vitro in response to acetylcholine, carbachol, met...
متن کاملOutcomes of esophageal surgery, especially of the lower esophageal sphincter.
This paper includes commentaries on outcomes of esophageal surgery, including the mechanisms by which fundoduplication improves lower esophageal sphincter (LES) pressure; the efficacy of the Linx™ management system in improving LES function; the utility of radiologic characterization of antireflux valves following surgery; the correlation between endoscopic findings and reported symptoms follow...
متن کاملNovel treatments of GERD: focus on the lower esophageal sphincter.
Up to 50% of patients with gastroesophageal reflux disease (GERD) still suffer from GERD symptoms despite proton pump inhibitor (PPI) therapy, indicating a need for new treatments. The lower esophageal sphincter (LES) plays a crucial role in maintaining the mechanical barrier necessary for prevention of gastric reflux. Transient LES relaxation (TLESR) is an important factor behind the occurrenc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology
سال: 1975
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)32407-2